Overview

The DHVI Biomolecular Interaction Analysis Facility, led by Munir Alam, provides specialized applications and support in Surface Plasmon Resonance (SPR) based biomolecular interaction analyses to basic and clinical researchers within the Duke Community. The facility offers state-of-the-art SPR BIAcore instruments for monitoring real time interactions and diverse sets of measurements that include binding affinity, kinetics, epitope mapping and resolution of binding mechanism and structure. ­

The BMI Facility has integrated Mass Spectrometry-Proteomics capability and offers applications in Mass Spectrometry based proteomics applications that include BIA-MS, in which a bound molecule is eluted and directly spotted on MALDI target plates for a MALDI mass spectrometry based identification of ligands for orphan receptors.